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The arthritis scores of all of the involved paws of each mouse (maximum possible score 16) were used to represent the overall disease severity and progression as follows: 0 = normal joint, 1 = swelling of one joint (toe/wrist/ankle/footpath), 2 = swelling of more than one joint, 3 = swelling of all joints and 4 = bursting of the skin/dysfunction or distortion of the joint